Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ.

Yumei QueXi ShuLangtao WangSai WangSiqi LiPingping HuXiaoyong Tong

Published in: British journal of pharmacology (2021)

The inactivation of SERCA2 C674 promotes the development of aortic aneurysms by disrupting the balance between PPARγ and NFAT/NF-κB. Our study highlights the importance of C674 redox status in regulating PPARγ to maintain aortic homeostasis.

Keyphrases

immune response
aortic valve
left ventricular
pulmonary artery
insulin resistance
aortic dissection
signaling pathway
nuclear factor
oxidative stress
lps induced
heart failure
metabolic syndrome
pi k akt
pulmonary arterial hypertension
atrial fibrillation
skeletal muscle