6-shogaol against 3-Nitropropionic acid-induced Huntington's disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway.

Ebtihaj J JambiAbdulaziz AlamriMuhammad AfzalFahad A Al-AbbasiSalwa D Al-QahtaniNaif A R AlmalkiAzizah Salim BawadoodSami I AlzareaNadeem SayyedImran Kazmi

Published in: PloS one (2024)

The present investigation demonstrated the neuroprotective effects of 6-shogaol in an experimental animal paradigm against 3-NPA-induced HD in rats. The suggested mechanism is supported by immunohistochemical analysis and western blots, although more research is necessary for definite confirmation.

Keyphrases

molecular docking
oxidative stress
molecular dynamics simulations
diabetic rats
signaling pathway
high glucose
lps induced
cancer therapy
pi k akt
drug induced
cerebral ischemia
inflammatory response
cell proliferation
subarachnoid hemorrhage