Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma.
Ahmed R GardouhMohammed A AttiaEman T EnanAlaaeldeen M ElbahaieRania A FouadMohamed El-ShafeyAmal M YoussefSuliman Y AlomarZinab Abd-Elhady AliSawsan A ZaitoneMona K E QushawyPublished in: Molecules (Basel, Switzerland) (2020)
The DOXY-PNPs showed greater antitumor potential against SEC grown in mice and greater values for Spearman's correlation coefficients were detected when correlation with tumor mass or apoptosis markers was examined; this is in comparison to free DOXY. Hence, DOXY-PNPs should be tested in other tumor types to further determine the utility of the current technique in preparing chemotherapeutic agents and enhancing their properties.