Maxillofacial Bone Involvement in Fibro-Osseous Lesions: Emphasizing the Significance of Differential Diagnosis.
Paolo GennaroLuigi GennariLinda LatiniGuido CavatiMargherita VannucchiFilippo GiovannettiFlavia CascinoPublished in: Journal of clinical medicine (2024)
The World Health Organization's (WHO) 2022 update on the classification of odontogenic and maxillofacial bone tumors has revolutionized diagnostic and treatment paradigms by integrating novel molecular insights. Fibro-osseous lesions of the maxillo-facial bones constitute a heterogeneous group encompassing fibrous dysplasia, Psammomatoid Ossifying Fibroma (PSOF), Juvenile Trabecular Ossifying Fibroma (JTOF), and other variants. Despite histological similarities, their distinct clinical manifestations and prognostic implications mandate precise differentiation. The intricacies of diagnosing fibro-osseous lesions pose challenges for pathologists, maxillofacial surgeons, dentists and oral surgeons, underscoring the importance of a systematic approach to ensure optimal patient management. Herein, we present two cases, fibrous dysplasia and Cemento-Ossifying Fibroma, detailing their clinical encounters and management strategies. Both patients provided informed consent for publishing their data and images, adhering to ethical guidelines.
Keyphrases
- bone mineral density
- end stage renal disease
- deep learning
- soft tissue
- ejection fraction
- quality improvement
- chronic kidney disease
- newly diagnosed
- machine learning
- electronic health record
- copy number
- convolutional neural network
- prognostic factors
- big data
- dna methylation
- thoracic surgery
- case report
- bone regeneration
- genome wide
- data analysis