Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy.

Kan Xing WuNatalie Jia Ying YeoChun Yi NgFlorence Wen Jing ChiohQiao FanXianfeng TianBinxia YangGunaseelan NarayananHui Min TayHan Wei HouN Ray DunnXinyi SuChui Ming Gemmy CheungChristine Cheung

Published in: BMC biology (2022)

Hyaluronidase-1 inhibition could be a potential therapeutic modality in preserving glycocalyx integrity and endothelial stability in ocular diseases with vascular origin.

Keyphrases

hyaluronic acid
endothelial cells
recombinant human
age related macular degeneration
optical coherence tomography
optic nerve