Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury.

Sin-Yu ChenYi-Ling ChenPo-Chen LiTai-Shan ChengYeh-Shiu ChuYi-Shan ShenHsin-Tung ChenWei-Ni TsaiChien-Ling HuangMartin SieberYuan-Chieh YehHsiao-Sheng LiuChi-Ling Chiang Chih-Hung ChangAndrew S LeeYen-Han TsengLy James LeeHsiu-Jung LiaoHon-Kan YipChi-Ying F Huang

Published in: Journal of biomedical science (2024)

This study reveals that the use of the CNP platform to stimulate and transfect WJ-MSCs could generate an abundance of let-7a-5p-enriched EVs, which underscores the therapeutic potential in countering inflammatory responses, fibrotic activation, and hyperoxia-induced lung injury. These results provide potential avenues for developing innovative therapeutic approaches for more effective interventions in ALI.

Keyphrases

oxidative stress
mesenchymal stem cells
diabetic rats
high glucose
physical activity
lps induced
high throughput
idiopathic pulmonary fibrosis
drug induced
human health
anaerobic digestion