Farnesoid X receptor promotes renal ischaemia-reperfusion injury by inducing tubular epithelial cell apoptosis.

Yao XuDawei LiJiajin WuMinfang ZhangXinghua ShaoLongmei XuLumin TangMinyan ZhuZhaohui NiMing ZhangShan Mou

Published in: Cell proliferation (2021)

These results established the pivotal importance of FXR inactivation in tubular epithelial cells after I/R injury. FXR may promote the apoptosis of renal tubular epithelial cells by inhibiting PI3k/Akt-mediated Bad phosphorylation to cause renal I/R damage.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
oxidative stress
cell death
high glucose
endoplasmic reticulum stress
acute myocardial infarction
coronary artery disease
acute coronary syndrome
acute ischemic stroke
atrial fibrillation
left ventricular