Sestrin2 alleviates palmitate-induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells.
Solji LeeJiha ShinYeji HongSeong Min ShinHye Won ShinJongdae ShinSung Ki LeeHwan-Woo ParkPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
Our study provides the relationship between Sestrin2, AMPK/mTORC1 pathway, and trophoblast function, suggesting that Sestrin2 may be a novel potential therapeutic target for the prevention of pregnancy complications.