The Growth Suppression Activity of Diosmin and PGV-1 Co-Treatment on 4T1 Breast Cancer Targets Mitotic Regulatory Proteins.

Hajidah MusyayyadahFebri WulandariAna Fiin NangimiAfivah Dewi AnggraeniMuthi' IkawatiEdy Meiyanto

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

Diosmin enhances the cytotoxic effect of PGV-1 synergistically on 4T1 cancer cells, which correlates to the increasing senescence and mitotic catastrophe. The synergistic effect of the co-treatment is likely to target AURKA, CDK1, and KIF11. The combination of PGV-1 and diosmin performs a potential as a combinatorial anticancer drug for TNBC.

Keyphrases

cell cycle
emergency department
dna damage
risk assessment
cell proliferation
replacement therapy