Urinary biomarkers of latent inflammation and fibrosis in children with vesicoureteral reflux.

Olga MorozovaDmitry MorozovDmitri PervouchineYulia EinavDarya LakomovaNatalya ZakharovaLubov SeverginaLarisa MaltsevaIvan Budnik

Published in: International urology and nephrology (2019)

The results support our hypothesis that successful correction of VUR is not sufficient to stop or reduce the latent inflammatory and fibrotic processes that have already started in the kidney regardless of the reflux grade and treatment option. Measuring the urinary levels of TGF-β1, VEGF, and MCP-1 may aid in the development of non-invasive, pathophysiologically relevant approach to diagnosis and monitoring of kidney injury and fibrosis in children with VUR.

Keyphrases

young adults
oxidative stress
endothelial cells
vascular endothelial growth factor
systemic sclerosis
transforming growth factor
idiopathic pulmonary fibrosis
combination therapy
signaling pathway
replacement therapy