Network pharmacology and molecular docking prediction, combined with experimental validation to explore the potential mechanism of Qishen Yiqi pills against HF-related cognitive dysfunction.

Song-Jie HanQian-Qian XuHai'e PanWen-Jing LiuQian-Qian DaiHong-Yuan LinHe-Rong CuiLiang-Zhen YouYu-Zhuo WuXiao-Hong WeiHong-Cai Shang

Published in: Journal of ethnopharmacology (2023)

This study clarified that QSYQ could improve HF-related cognitive dysfunction by modulating cAMP-CREB-BDNF signals. It provides a rich basis for the potential mechanism of QSYQ in the treatment of heart failure with cognitive dysfunction.

Keyphrases

molecular docking
heart failure
acute heart failure
molecular dynamics simulations
signaling pathway
binding protein
cardiac resynchronization therapy
risk assessment
drug induced