Long-term glucocorticoid exposure and incident cardiovascular diseases - the Lifelines cohort.
Eline S van der ValkMostafa MohseniAnand M IyerMaartje van den HurkRobin LengtonSusanne KuckuckVincent L WesterPieter J M LeenenWillem A DikJenny A VisserMaryam KavousiMina MirzaianSjoerd A A van den BergElisabeth F C van RossumPublished in: The Journal of clinical endocrinology and metabolism (2024)
In this large, prospective cohort study, we found that long-term cortisone levels, measured in scalp hair, represent a relevant and significant predictor for future cardiovascular diseases in younger individuals. These results highlight glucocorticoid action as possible treatment target for CVD prevention, where hair glucocorticoid measurements could help identify individuals that may benefit from such treatments.