Novel treatment strategy of targeting epigenetic dysregulation in pancreatic neuroendocrine tumors.

Clara ZhuGeorgianna SandilosJohn WilliamsonRobert EmeryRebecca PlatoffUpasana JonejaNimish K AcharyaAndrew LinJeremy BadachBrian ZilbermanJozef MadzoJaroslav JelinekPing ZhangYoung Ki Hong

Published in: Surgery (2023)

Epigenetic dysregulation with DNA methyltransferase 1 is associated with pancreatic neuroendocrine tumors and is a potential targetable strategy. 5-azacytidine and chemotherapy in combination can reduce cell proliferation, upregulate silenced tumor suppressor genes, and decrease in vivo tumors in pancreatic neuroendocrine tumors.

Keyphrases

neuroendocrine tumors
cell proliferation
dna methylation
gene expression
genome wide
circulating tumor
squamous cell carcinoma
cell cycle
cell free
drug delivery
transcription factor
circulating tumor cells
human health
genome wide identification