Cell surface marker-based capture of neoantigen-reactive CD8 + T-cell receptors from metastatic tumor digests.
Praveen D ChataniFrank J LoweryNeilesh B ParikhKyle J HitscherichRami YossefVictoria HillJared J GartnerBiman PariaMaria FlorentinSatyajit RayAlakesh BeraMaria ParkhustPaul F RobbinsSri KrishnaSteven A RosenbergPublished in: Journal for immunotherapy of cancer (2023)
represents a streamlined effective approach to rapidly identify neoantigen-reactive TCRs to design engineered cellular immunotherapies against cancer.