Molecular characterisation of pancreatic ductal adenocarcinoma with NTRK fusions and review of the literature.
Michael J AllenAmy ZhangPrashant BaviJaesung C KimGun Ho JangDeirdre KellySheron PereraRob E DenrocheFaiyaz NottaJulie M WilsonAnna DoddStephanie RamotarShawn HutchinsonSandra E FischerRobert C GrantSteven GallingerJennifer J KnoxGrainne M O'KanePublished in: Journal of clinical pathology (2021)
NTRK fusions are rare; however, with emerging therapeutic options targeting these fusions, detection is vital. Reflex testing for KRAS mutations and subsequent RNA-based screening could help identify these cases in PDAC.