Relationships between body fat distribution and metabolic syndrome traits and outcomes: A mendelian randomization study.
Brian HuangJohn DePaoloRenae L JudyGabrielle ShaktWalter R WitscheyMichael G LevinVictoria M GershuniPublished in: PloS one (2023)
A MR analysis of ASAT, GFAT, and VAT depots and their relative ratios with metabolic syndrome related traits and outcomes revealed that increased absolute and relative GFAT were associated with a favorable cardiometabolic profile independently of BMI. These associations highlight the importance of body fat distribution in obesity and more precise means to categorize obesity beyond BMI.