A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates.
Asif NoorJiawei LiGeorge N KhairallahZhen LiHossein GhariAlison J CantyAlireza AriafardPaul S DonnellyRichard A J O'HairPublished in: Chemical communications (Cambridge, England) (2018)
A new palladium mediated "one pot" synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was discovered by gas-phase experiments and theoretical studies. Palladium-mediated decarboxylation of aromatic carboxylic acids followed by addition of substituted isothiocyanates leads to the corresponding thioamide derivatives.