NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage.

William S DoddImaray NodaMelanie MartinezKoji HosakaBrian L Hoh

Published in: Journal of neuroinflammation (2021)

We demonstrate a novel association between NLRP3-mediated neuroinflammation and cerebrovascular dysfunction in both the early and delayed phases after SAH. MCC950 and other NLRP3 inhibitors could be promising tools in the development of therapeutics for EBI and DCI.

Keyphrases

subarachnoid hemorrhage
brain injury
cerebral ischemia
nlrp inflammasome
traumatic brain injury
lipopolysaccharide induced
lps induced
cognitive impairment