The Pharmacological Effects of Silver Nanoparticles Functionalized with Eptifibatide on Platelets and Endothelial Cells.

Justyna HajtuchEliza IwickaAnna SzczoczarzDamian Jozef FlisElżbieta MegielPiotr CieciórskiMarek Witold RadomskiMaria Jose Santos-Martinez Iwona Inkielewicz-Stepniak

Published in: International journal of nanomedicine (2022)

AgNPs-EPI show anti-aggregatory activity at concentrations lower than those required by the free drug acting via regulation of platelet aggregation, blood coagulation, and endothelial cell activity. Our results provide proof-of-principle evidence that AgNPs may be used as an effective delivery platform for antiplatelet drugs.

Keyphrases

silver nanoparticles
endothelial cells
high glucose
vascular endothelial growth factor
emergency department
quantum dots
high resolution
mass spectrometry
molecularly imprinted
red blood cell