Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort.
Yujia ZhaoYunjia LaiHilde KonijnenbergJosé María HuertaAna Vinagre-AragonJara Anna SabinJohnni HansenDafina PetrovaCarlotta SacerdoteRaul Zamora-RosValeria PalaAlicia K HeathSalvatore PanicoMarcela GuevaraGiovanna MasalaChristina M LillGary W MillerSusan PetersRoel VermeulenPublished in: Neurology (2024)
This study demonstrates that the neuroprotection of coffee on PD is attributed to caffeine and its metabolites by detailed quantification of plasma caffeine and its metabolites years before diagnosis.