Higher entropy observed in SARS-CoV-2 genomes from the first COVID-19 wave in Pakistan.
Najia Karim GhanchiAsghar NasirKiran Iqbal MasoodSyed Hani AbidiSyed Faisal MahmoodAkbar KanjiSafina RazzakWaqasuddin KhanSaba ShahidMaliha YameenAli RazaJavaria AshrafZeeshan AnsarMohammad Buksh DharejoNazneen IslamZahra HasanRumina HasanPublished in: PloS one (2021)
The higher entropy and diversity observed in early pandemic as compared with later strains suggests increasing stability of the genomes in subsequent COVID-19 waves. This would likely lead to the selection of site-specific changes that are advantageous to the virus, as has been currently observed through the pandemic.