High-Density Lipoprotein Particle Concentration and Size Predict Incident Coronary Artery Disease Events in a Cohort With Type 1 Diabetes.
Tina CostacouTomas VaisarRachel G MillerWilliam Sean DavidsonJay W HeineckeTrevor John OrchardKarin E BornfeldtPublished in: Journal of the American Heart Association (2024)
Lower concentrations of total HDL-P and HDL subpopulations were positively associated with incident CAD independently of HDL-cholesterol, apolipoprotein A1, and other common CVD risk factors. Extra-small HDL was a much stronger predictor of risk than the other HDLs. Our data are consistent with the proposal that extra-small HDL plays a critical role in cardioprotection in type 1 diabetes, mediated by macrophage cholesterol efflux by the ABCA1 pathway.
Keyphrases
- coronary artery disease
- high density
- type diabetes
- risk factors
- cardiovascular disease
- low density lipoprotein
- adipose tissue
- electronic health record
- percutaneous coronary intervention
- insulin resistance
- machine learning
- glycemic control
- atrial fibrillation
- acute coronary syndrome
- deep learning
- transcatheter aortic valve replacement