Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies.

Harry RidgwayGraham J MooreLaura Kate Gadanec Anthony Zulli Vasso ApostolopoulosWeronika HoffmannKatarzyna Węgrzyn Niki VassilakiGeorge MpekoulisMarios ZouridakisPetros GiastasVeroniki P VidaliKonstantinos KelaidonisMinos-Timotheos MatsoukasMarios DimitriouThomas Mauromoustakos Sotirios Tsiodras Vassilis G GorgoulisIoannis KarakasiliotisChristos T Chasapis John M Matsoukas

Published in: Expert opinion on therapeutic targets (2024)

This study reports the discovery of a new class of benzimidazole-based sartans that significantly inhibit SARS-CoV-2, likely due to their interaction with ACE2.

Keyphrases

sars cov
angiotensin converting enzyme
angiotensin ii
respiratory syndrome coronavirus
molecular docking
high throughput
hydrogen peroxide
emergency department
nitric oxide
molecular dynamics simulations