A decrease in brown adipose tissue activity is associated with weight gain during chemotherapy in early breast cancer patients.

Angeline GinzacBertrand BarresMarion ChanchouEmilie GadéaIoana MolnarCharles MerlinBruno CoudertEmilie ThivatXavier Durando

Published in: BMC cancer (2020)

This study is the first to highlight in a large cohort of patients the negative impact of chemotherapy on brown adipose tissue activity. Weight gain during chemotherapy could thus potentially be explained in part by a decrease in brown adipose tissue activity.

Keyphrases

weight gain
adipose tissue
body mass index
end stage renal disease
ejection fraction
newly diagnosed
birth weight
insulin resistance
prognostic factors
high fat diet
squamous cell carcinoma
metabolic syndrome
radiation therapy
physical activity
skeletal muscle
patient reported
chemotherapy induced