Numerous studies have shown the detrimental health effects of tobacco smoking on bone volume and strength in human and animal models. Little is known regarding the impacts of e-cigarettes, a form of smoke-less nicotine intake, despite their growing population of users. This study uses murine models to evaluate the effects of exposure to e-cigarette aerosols (JUUL) on bone structure and strength through micro-CT imaging and mechanical testing. JUUL mice had more trabecular bone in thickness and volume, yet lower ultimate stress and modulus values in the cortical bone than the control mice. These outcomes suggest that, although vaping can result in a higher bone volume, this bone is weaker than average. E-cigarettes should be examined more closely regarding adolescence and long-term consequences on skeletal health.
Keyphrases
- bone mineral density
- smoking cessation
- soft tissue
- bone loss
- bone regeneration
- public health
- depressive symptoms
- body composition
- endothelial cells
- high resolution
- type diabetes
- risk assessment
- health information
- physical activity
- body mass index
- optical coherence tomography
- high fat diet induced
- replacement therapy
- contrast enhanced
- heat stress
- pet ct
- fluorescence imaging
- glycemic control