Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats.

Anusara Aranarochana Apiwat SirichoatWanassanun PannangrongPeter WigmoreJariya Umka Welbat

Published in: Oxidative medicine and cellular longevity (2021)

We found that melatonin was able to counteract these neurotoxic effects, acting as a neuroprotectant in VPA-induced memory hippocampal neurogenesis impairment by preventing intracellular oxidative stress and increasing antioxidant activity.

Keyphrases

oxidative stress
diabetic rats
cerebral ischemia
dna damage
ischemia reperfusion injury
neural stem cells
induced apoptosis
high glucose
working memory
reactive oxygen species
drug induced
young adults
signaling pathway
childhood cancer
stress induced