Design and Evaluation of Composite Magnetic Iron-Platinum Nanowires for Targeted Cancer Nanomedicine.
Abu Bakr A NanaThashree MarimuthuDaniel WamwangiPierre P D KondiahYahya Essop ChoonaraPublished in: Biomedicines (2023)
The purpose of the study was to synthesize and investigate the influence of geometrical structure, magnetism, and cytotoxic activity on core-shell platinum and iron-platinum (Fe/Pt) composite nanowires (NWs) for potential application in targeted chemotherapeutic approaches. The Pt-NWs and Fe/Pt composite NWs were synthesized via template electrodeposition, using anodic aluminum oxide (AAO) membranes. The Fe/Pt composite NWs (Method 1) was synthesized using two electrodeposition steps, allowing for greater control of the diameter of the NW core. The Fe/Pt composite NWs (Method 2) was synthesized by pulsed electrodeposition, using a single electrolytic bath. The properties of the synthesized NWs were assessed by high-resolution transmission electron microscopy (HRTEM), Raman spectroscopy, powder X-ray diffraction (XRD), inductively coupled plasma-optical emission spectrometry (ICP-OES), vibrating-sample magnetometry (VSM), and surface charge (zeta potential). A microscopy image analysis of the NWs revealed the presence of high-aspect-ratio NWs with nominal diameters of 40-50 nm and lengths of approximately <4 µm. The obtained powder XRD patterns confirmed the presence of a polycrystalline structure for both Pt NWs and Fe/Pt composite NWs. The potential utility of the synthesized NW nanoplatforms for anticancer activity was investigated using Tera 1 cells and Mouse 3T3 cells. Pt-NWs displayed modest cytotoxic activity against Tera 1 cells, while the Fe/Pt composite NWs (both Methods 1 and 2) demonstrated enhanced cytotoxic activity compared to the Pt-NWs on Tera 1 cells. The Fe/Pt composite NWs (Method 1) displayed ferromagnetic behavior and enhanced cytotoxic activity compared to Pt-NWs on Tera 1 cells, thus providing a sound basis for future magnetically targeted chemotherapeutic applications.
Keyphrases
- high resolution
- induced apoptosis
- cell cycle arrest
- cancer therapy
- electron microscopy
- raman spectroscopy
- cell death
- endoplasmic reticulum stress
- oxidative stress
- squamous cell carcinoma
- photodynamic therapy
- gold nanoparticles
- signaling pathway
- cell proliferation
- optical coherence tomography
- drug delivery
- deep learning
- machine learning
- high throughput
- current status
- ms ms
- human health
- high speed
- young adults
- atomic force microscopy
- squamous cell
- simultaneous determination