The Impact Of Succinate Dehydrogenase Gene (SDH) Mutations In Renal Cell Carcinoma (RCC): A Systematic Review.
Seyed Mohammad Kazem AghamirRamin HeshmatMehdi EbrahimiSeyed Ebrahim KetabchiSomayeh Parichehreh DizajiSeyed Mohammad TavangarPublished in: OncoTargets and therapy (2019)
RCC as an aggressive type of kidney cancer needs some biomarkers to be diagnosed exactly. It was shown recently that the succinate dehydrogenase gene variations can provide this diagnostic and prognostic biomarker. For this purpose, SDHB rs772551056 associated with its protein expression alterations can be taken into account. It is possible that a novel mutation of SDHA (c.2T>C: p.M1T) can provide evidence of GIST associated with RCC as well.