A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti-PD-1 Resistance through Effects on the Gut Microbiota.
Meriem MessaoudeneReilly PidgeonCorentin RichardMayra PonceKhoudia DiopMyriam BenlaifaouiAlexis Nolin-LapalmeFlorent CauchoisJulie MaloWiam BelkaidStephane IsnardYves FradetLharbi DridiDominique VelinPaul OsterDidier RaoultFrançois GhiringhelliRomain BoidotSandy ChevrierDavid T KyselaYves V BrunEmilia Liana FalconeGeneviève PilonFlorian Plaza OñateOscar Gitton-QuentEmmanuelle Le ChatelierSylvere DurandGuido KroemerArielle ElkriefAndré MaretteBastien CastagnerBertrand RoutyPublished in: Cancer discovery (2022)
The polyphenol castalagin isolated from a berry has an antitumor effect through direct interactions with commensal bacteria, thus reprogramming the tumor microenvironment. In addition, in preclinical ICI-resistant models, castalagin reestablishes the efficacy of anti-PD-1. Together, these results provide a strong biological rationale to test castalagin as part of a clinical trial. This article is highlighted in the In This Issue feature, p. 873.