Osteolytic effects of tumoral estrogen signaling in an estrogen receptor-positive breast cancer bone metastasis model.
Julia N ChengJennifer B FryeSusan A WhitmanAndrew G KunihiroJulia A BrickeyJanet L Funk
Published in: Journal of cancer metastasis and treatment (2021)
These results suggest that tumoral ERα signaling may contribute to ER+ BMET-associated osteolysis, potentially explaining the greater predilection for ER+ tumors to form clinically-evident osteolytic BMETs.