Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study.
Jérôme PuginThomas DaixJean-Luc PaganiDavide MorriAngelo GiacomucciPierre-François DequinChristophe GuittonYok-Ai QueGianluca ZaniDavid BrealeyAlain LepapeBen Creagh-BrownDuncan WyncollDaniela SilengoIrina IrincheevaLaurie GirardFabien RebeaudIwan MaerkiPhilippe EggimannBruno FrancoisPublished in: Critical care (London, England) (2021)
While the diagnostic accuracy of PSP, CRP and PCT for sepsis were similar in this cohort, serial PSP measurement demonstrated an increase of this marker the days preceding the onset of signs necessary to clinical diagnose sepsis. This observation justifies further evaluation of the potential clinical benefit of serial PSP measurement in the management of critically ill patients developing nosocomial sepsis. Trial registration The study has been registered at ClinicalTrials.gov (no. NCT03474809), on March 16, 2018. https://www.clinicaltrials.gov/ct2/show/NCT03474809?term=NCT03474809&draw=2&rank=1 .
Keyphrases
- staphylococcus aureus
- intensive care unit
- acute kidney injury
- septic shock
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- computed tomography
- mechanical ventilation
- magnetic resonance imaging
- study protocol
- magnetic resonance
- risk assessment
- small molecule
- acinetobacter baumannii
- positron emission tomography
- protein protein
- human health
- extracorporeal membrane oxygenation