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15-color highly sensitive flow cytometry assay for post anti-CD19 targeted therapy (anti-CD19-CAR-T and blinatumomab) measurable residual disease assessment in B-lymphoblastic leukemia/lymphoma: Real-world applicability and challenges.

Gaurav ChatterjeePriyanka DhendeSimpy RajVruksha ShettySitaram GhogaleNilesh DeshpandeKarishma GiraseJagruti PatilAastha KalraGaurav NarulaKajal DalviChetan DhamneNirmalya Roy MoulikSweta RajpalNikhil V PatkarShripad BanavaliSumeet GujralPapagudi G SubramanianPrashant Ramesh Tembhare
Published in: European journal of haematology (2023)
We standardized a highly sensitive 15-color BMRD assay with a non-CD19-based gating strategy for patients receiving anti-CD19 immunotherapy. We also described the immunophenotypes of recurrently occurring low-level populations that can be misinterpreted as MRD in real-world practice.
Keyphrases
  • flow cytometry
  • nk cells
  • high throughput
  • healthcare
  • acute lymphoblastic leukemia
  • primary care
  • acute myeloid leukemia
  • mass spectrometry
  • living cells