Ultrasensitive Determination of Tetrabromobisphenol A by Covalent Organic Framework Based Solid Phase Microextraction Coupled with Constant Flow Desorption Ionization Mass Spectrometry.

Rapid detection of ultratrace pollutants in complex matrixes is a great challenge for studying their environmental behaviors and impacts. In this work, a method is developed by combining covalent organic framework (COF) based solid phase microextraction (SPME) with constant flow desorption ionization mass spectrometry for rapid detection of trace tetrabromobisphenol A (TBBPA) in multiple water media. The limits of detection and qualification are 0.92 and 3.1 ng L-1 for TBBPA, respectively. The linear range is between 0.01 and 10 μg L-1 ( R2 = 0.9992), and the relative standard deviations with single fiber and multiple fibers are 6.4% and 6.7% (0.1 μg L-1, n = 9), respectively. The detection of nanogram per liter levels of TBBPA in tap water, river water, seawater, and beverage can be achieved in 7 min.