Castration-resistant prostate cancer with bone metastases: toward the best therapeutic choice.
Giandomenico RovielloMartina CatalanoCarlotta OttanelliRoberta GiorgioneVirginia RossiElisabetta GambaleChiara CasadeiUgo De GiorgiLorenzo AntonuzzoPublished in: Medical oncology (Northwood, London, England) (2022)
The treatment landscape for metastatic castration-resistant prostate cancer has evolved extremely in recent years and several drug classes are now available. Nonetheless, the lack of validated predictive biomarkers makes therapeutic choice and the best sequential approach difficult. The location of the metastatic site could be a valid criterion for choosing among the treatment options available. Although bone remains the most frequent metastatic site and a possible target for many drugs, recent data suggest a profound shift in the disease spectrum with visceral metastases increasing incidence. This review describes the presently available and ongoing therapies for patients with CRPC and bone metastases, focusing on the role of bone metastases as a possible driver for selecting therapies in these patients.
Keyphrases
- squamous cell carcinoma
- small cell lung cancer
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- risk factors
- peritoneal dialysis
- prognostic factors
- type diabetes
- intellectual disability
- skeletal muscle
- decision making
- soft tissue
- autism spectrum disorder
- postmenopausal women
- smoking cessation
- bone regeneration