Frequent overexpression of HER3 in brain metastases from breast and lung cancer.

Erwin Tomasich Ariane Steindl Christina Paiato Teresa Hatziioannou Markus Kleinberger Luzia Berchtold Rainer Puhr Johannes A Hainfellner Leonhard Müllauer Georg Widhalm Franziska Eckert Rupert Bartsch Gerwin Heller Matthias Preusser Anna Sophie Berghoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

HER3 is highly abundant in BM of BCa and NSCLC. Given the promising results of antibody-drug conjugates in extracranial disease, BM specific trials that target HER3 are warranted.

Keyphrases

brain metastases
small cell lung cancer
internal carotid artery
cell proliferation
transcription factor
cancer therapy
drug delivery
advanced non small cell lung cancer