A-DA'D-A fused-ring small molecule-based nanoparticles for combined photothermal and photodynamic therapy of cancer.

Bing LuZhecheng ZhangDanni JinXiaolei YuanJin WangYue Ding Yang Wang Yong Yao

Published in: Chemical communications (Cambridge, England) (2021)

New nanoparticles (Y6 NPs) based on the A-DA'D-A fused-ring conjugated small molecule Y6 have been prepared for the combined photothermal and photodynamic therapy of cancer. Y6 NPs show excellent light absorption from 300 to 900 nm, a good photothermal conversion efficiency of 57% and reactive oxygen species generation capability. The high photothermal conversion ability and superior photodynamic activity of Y6 NPs endow them with great potential for cancer therapy.

Keyphrases

photodynamic therapy
small molecule
cancer therapy
fluorescence imaging
papillary thyroid
reactive oxygen species
drug delivery
squamous cell
protein protein
climate change
drug release