Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms.

David Da CostaChloé Exbrayat-HéritierBasile RambaudSimon MegyRaphaël TerreuxBernard VerrierCharlotte Primard

Published in: Journal of nanobiotechnology (2021)

Correlating the carrier retention capacity in biofilms with the treatment efficacy, positively charged rifampicin-loaded PLA nanoparticles are therefore proposed as an adapted and promising approach to improve antibiotic delivery in S. aureus biofilms.

Keyphrases

candida albicans
staphylococcus aureus
drug delivery
mycobacterium tuberculosis
cancer therapy
pulmonary tuberculosis
biofilm formation
wound healing
combination therapy
walled carbon nanotubes
cystic fibrosis