Effects of analgesics on bone mineral density: A longitudinal analysis of the prospective SWAN cohort with three-group matching weights.
Kazuki YoshidaZhi YuGail A GreendaleKristine RuppertYinjuan LianSara K TedeschiTzu-Chieh LinSebastien HaneuseRobert J GlynnSonia Hernández-DíazDaniel H SolomonPublished in: Pharmacoepidemiology and drug safety (2017)
The BMD decline over time was similar among the 3 groups. However, 5 years of continuous opioid use may be associated with a greater BMD decline than 5 years on other analgesics. Further studies examining the relationship between very long-term persistent opioid use and BMD are warranted.