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Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes.

Xiaona CuiJin FengTianjiao WeiLinxi ZhangShan LangKun YangJin YangJunling LiuMichael SterrHeiko LickertRui WeiTianpei Hong
Published in: Diabetologia (2022)
Our findings demonstrate that liver-derived FGF21 is involved in the GCGR antagonism-induced beta cell regeneration in a mouse model of type 2 diabetes.
Keyphrases
  • mouse model
  • single cell
  • stem cells
  • cell therapy
  • oxidative stress
  • wound healing
  • endothelial cells