Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes.

Xiaona Cui Jin Feng Tianjiao Wei Linxi Zhang Shan Lang Kun Yang Jin YangJunling LiuMichael SterrHeiko Lickert Rui Wei Tianpei Hong

Published in: Diabetologia (2022)

Our findings demonstrate that liver-derived FGF21 is involved in the GCGR antagonism-induced beta cell regeneration in a mouse model of type 2 diabetes.

Keyphrases

mouse model
single cell
stem cells
cell therapy
oxidative stress
wound healing
endothelial cells