Histamine causes an imbalance between pro-angiogenic and anti-angiogenic factors in the retinal pigment epithelium of diabetic retina via H4 receptor/p38 MAPK axis.

Byung Joo LeeHye Eun ByeonChang Sik ChoYoung Ho KimJin Hyoung KimJeong-Hwan CheSeung Hyeok SeokJung-Won KwonJeong Hun KimKihwang Lee

Published in: BMJ open diabetes research & care (2021)

Taken together, HRH4 was a critical regulator of VEGF, IL-6 and PEDF in the RPE under hyperglycemic conditions and the p38 mitogen-activated protein kinase pathway mediated this regulatory mechanism.

Keyphrases

transcription factor
vascular endothelial growth factor
endothelial cells
anti inflammatory
diabetic retinopathy
protein kinase
tyrosine kinase
optic nerve
binding protein