6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.
Joshua R GurrTimothy J O'DonnellYuheng LuoWesley Y YoshidaMary L HallAlejandro M S MayerRui SunPhilip G WilliamsPublished in: Journal of natural products (2020)
Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B2 and superoxide anion (O2-) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.
Keyphrases
- escherichia coli
- inflammatory response
- molecular docking
- high throughput
- oxidative stress
- toll like receptor
- high resolution
- hydrogen peroxide
- ionic liquid
- lps induced
- liquid chromatography
- neuropathic pain
- high performance liquid chromatography
- mass spectrometry
- spinal cord injury
- immune response
- klebsiella pneumoniae
- pseudomonas aeruginosa
- cystic fibrosis
- single cell
- drug induced
- simultaneous determination
- candida albicans