Developing novel catalysts with high activity and high stability for the methanol oxidation reaction (MOR) is of great importance for the ever-broader applications of methanol fuel cells. Herein, we present a facile technique for synthesizing Au 10 Pt 1 @MnO 2 catalysts using a wet chemical method and investigate their catalytic performance for the MOR. Notably, the Au 10 Pt 1 @MnO 2 -M composite demonstrated a significantly high peak mass activity of 15.52 A mg(Pt) -1 , which is 35.3, 57.5, and 21.9 times greater than those of the Pt/C (0.44 A mg(Pt) -1 ), Pd/C (0.27 A mg(Pt) -1 ), and Au 10 Pt 1 (0.71 A mg(Pt) -1 ) catalysts, respectively. Comparative analysis with commercial Pt/C and Pd/C catalysts, as well as Au 10 Pt 1 HSNRs, revealed that the Au 10 Pt 1 @MnO 2 -M composite exhibited the lowest initial potential, the highest peak current density, and superior CO anti-poisoning capability. The results demonstrate that the introduction of MnO 2 nanosheets, with excellent oxidation capability, not only significantly increases the reactive sites, but also promotes the reaction kinetics of the catalyst. Furthermore, the high surface area of the MnO 2 nanosheets facilitates charge transfer and induces modifications in the electronic structure of the composite. This research provides a straightforward and effective strategy for the design of efficient electrocatalytic nanostructures for MOR applications.