Neurofilament light chain - a possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?

Our findings demonstrate the translational potential of NfL as a blood-based fluid biomarker for SE. This is less evident for chronic epilepsy, as in this case higher NfL levels could only be detected in ISF and CSF, and not in plasma-acknowledging the invasive nature of CSF sampling in chronic epilepsy follow-up.