Speech biomarkers in Huntington disease: a cross-sectional study in pre-symptomatic, prodromal and early manifest stages.

Tomas KoubaWiebke FrankTereza TykalovaAlzbeta MühlbäckJiří KlempířKatrin S LindenbergG Bernhard LandwehrmeyerJan Rusz

Published in: European journal of neurology (2023)

Speech abnormalities in HD are associated with other motor and cognitive deficits and are measurable already in premanifest stages of HD. Therefore, automated speech analysis might represent a quantitative HD biomarker with potential for assessing disease progression.

Keyphrases

machine learning
physical activity
deep learning
high resolution
high throughput
parkinson disease
risk factors
climate change