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Copper(II)-Mediated Ring Opening/Alkynylation of Tertiary Cyclopropanols by Using Nonmodified Terminal Alkynes.

Bu-Qing ChengSi-Xuan ZhangYan-Ying CuiXue-Qiang ChuWei-Dong RaoHaiyan XuGuo-Zhi HanZhi-Liang Shen
Published in: Organic letters (2020)
The copper(II)-mediated ring opening/alkynylation of cyclopropanol by employing inexpensive and commercially available terminal alkyne is developed. The reactions proceeded efficiently to afford synthetically useful alk-4-yn-1-ones in moderate to good yields with good functional group tolerance. Control experiments showed that the reaction presumably proceeds via the formation of intermediates of copper homoenolate and/or alkynylcopper species.
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