DNA methylation of exercise-responsive genes differs between trained and untrained men.
Carla GeigerMaria NeedhamsenEric B EmanuelssonJessica NorrbomKaren SteindorfCarl Johan SundbergStefan M ReitznerMaléne E LindholmPublished in: BMC biology (2024)
Endurance- compared to resistance-trained athletes and untrained individuals demonstrated a different DNA methylation signature of selected skeletal muscle genes, which may influence transcriptional dynamics following a bout of acute exercise. Skeletal muscle fiber type distribution is associated with methylation of fiber type specific genes. Our results suggest that the baseline DNA methylation landscape in skeletal muscle influences the transcription of regulatory genes in response to an acute exercise bout.
Keyphrases
- genome wide
- skeletal muscle
- dna methylation
- resistance training
- high intensity
- gene expression
- body composition
- insulin resistance
- transcription factor
- liver failure
- genome wide identification
- physical activity
- copy number
- bioinformatics analysis
- respiratory failure
- drug induced
- type diabetes
- metabolic syndrome
- middle aged
- hepatitis b virus
- extracorporeal membrane oxygenation