Mucosal-Associated Invariant T Cell Dysregulation Correlates With Conjugated Bilirubin Level in Chronic HBV Infection.

Yu LiuPeng ZhuWei WangXiaosheng TanChuanqiao LiuYingshan ChenRongjuan PeiXue ChengMi WuQing GuoHongmei LiangZhihui LiangJia LiuYang XuXiongwen WuXiufang Weng

Published in: Hepatology (Baltimore, Md.) (2021)

We reveal the MR1-dependent, anti-HBV potential of MAIT cells and identify conjugated bilirubin as a major factor dysregulating its frequency and function in chronic HBV-infected patients, suggesting a therapeutic target for MAIT-cell-based immunity against chronic HBV infection.

Keyphrases

hepatitis b virus
liver failure
photodynamic therapy
single cell
induced apoptosis

magnetic resonance
cell cycle arrest
gene expression
stem cells
cell therapy

magnetic resonance imaging
cell death
genome wide
signaling pathway
risk assessment

oxidative stress
bone marrow
ulcerative colitis
pi k akt