Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy.
Nada El-MahmoudiGuillaume RastoldoEmna MarouaneDavid PéricatIsabelle WatabeAlain TonettoCharlotte HautefortChristian ChabbertFrancesca SargoliniBrahim TighiletPublished in: Journal of neuroinflammation (2021)
We show here, for the first time, that acute anti-inflammatory treatment alters the expression of the adaptive plasticity mechanisms in the deafferented vestibular nuclei and generates enhanced and prolonged vestibular and postural deficits. These results strongly suggest a beneficial role for acute endogenous neuroinflammation in vestibular compensation. They open the way to a change in dogma for the treatment and therapeutic management of vestibular patients.
Keyphrases
- liver failure
- anti inflammatory
- respiratory failure
- aortic dissection
- traumatic brain injury
- drug induced
- hepatitis b virus
- hearing loss
- newly diagnosed
- intensive care unit
- lipopolysaccharide induced
- brain injury
- cognitive impairment
- replacement therapy
- chronic kidney disease
- blood brain barrier
- long non coding rna