PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT40.

Takahito MoriwakiAkari YoshimuraYuki TamariHiroyuki SasanumaShunichi TakedaMasayuki SekiKeizo Tano

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2021)

PRDX1 is essential in chicken DT40 cells and plays an important role in maintaining intracellular ROS homeostasis (or in the fine-tuning of cellular ROS levels). Cells deficient in PRDX1 may be used as an endogenously deregulated ROS model to elucidate the physiological roles of ROS in maintaining proper cell growth.

Keyphrases

reactive oxygen species
cell death
induced apoptosis
cell cycle arrest
dna damage
signaling pathway
pi k akt