Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer.
Maria Letizia MottiRosaria MeccarielloPublished in: International journal of environmental research and public health (2019)
Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the prevention, diagnosis, and treatment of human diseases. In this respect, the depth of knowledge of epigenetic mechanisms is fundamental to preserving health status and to developing targeted interventions. In this minireview, we summarize the epigenetic modulation of the KISS1 gene in order to provide an example of epigenetic regulation in health and disease.
Keyphrases
- dna methylation
- human health
- gene expression
- genome wide
- risk assessment
- healthcare
- endothelial cells
- induced apoptosis
- physical activity
- public health
- metabolic syndrome
- small molecule
- cardiovascular disease
- squamous cell carcinoma
- climate change
- papillary thyroid
- weight loss
- high throughput
- type diabetes
- endoplasmic reticulum stress
- transcription factor
- cell cycle arrest
- squamous cell
- oxidative stress
- induced pluripotent stem cells
- nucleic acid